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3 edition of clinical potential of interferons found in the catalog.

clinical potential of interferons

International Conference on Clinical Potentials of Interferons in Viral Diseases and Malignant Tumors (1980 OМ„iso-machi, Japan)

clinical potential of interferons

treatment of viral diseases and malignant tumors : proceedings of the International Conference on Clinical Potentials of Interferons in Viral Diseases and Malignant Tumors, held December 2-4, 1980

by International Conference on Clinical Potentials of Interferons in Viral Diseases and Malignant Tumors (1980 OМ„iso-machi, Japan)

  • 108 Want to read
  • 24 Currently reading

Published by University of Tokyo Press in Tokyo .
Written in English

    Subjects:
  • Interferon -- Testing -- Congresses.,
  • Cancer -- Chemotherapy -- Congresses.,
  • Virus diseases -- Chemotherapy -- Congresses.

  • Edition Notes

    Includes bibliographical references and index.

    Statementedited by Reisaku Kōno, Jan Vilček.
    SeriesJapan Medical Research Foundation publication ;, no. 15
    ContributionsKōno, Reisaku, 1915-, Vilček, J., 1933-
    Classifications
    LC ClassificationsRC271.I46 I57 1980
    The Physical Object
    Paginationxiv, 404 p. :
    Number of Pages404
    ID Numbers
    Open LibraryOL3092684M
    ISBN 100860083136
    LC Control Number82195891

    This text aims to provide a comprehensive body of information concerning the clinical usage of interferons. The book covers the history of the development and introduction of the interferons, as well as chapters on their mechanism of action and a look to the future. To accomplish this coherently it is necessary also to review briefly what led to the discovery of interferons, why their clinical applications were so slow in coming, and the impact of interferon.

    This book is an update of Interferon, published in by Dr. Jan Vilcek. The field of interferon research has since expanded from its former narrow treatment of interferon strictly as an antiviral substance, such that The Interferon System now encompasses cellular modulations ranging from immune alterations to cell proliferative restrictions to antitumor activities. Eleanor Fish, a researcher with Toronto’s University Health Network, said that awareness of interferon as a potential COVID treatment has been slow to .

    An exploratory study on a cohort of 77 confirmed COVID cases in Wuhan showed treatment with the antiviral IFN-α2b reduced viral clearance time . Clinical Implications of Interferon NAbs. Whether NAbs conclusively diminish or abrogate the therapeutic effects of beta-interferons has been a subject of much debate [8]. Nevertheless, it appears that persistently high NAb titers are associated with a negative impact upon the therapeutic effects of beta-interferons [9,19,25,30,38].


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Clinical potential of interferons by International Conference on Clinical Potentials of Interferons in Viral Diseases and Malignant Tumors (1980 OМ„iso-machi, Japan) Download PDF EPUB FB2

Interferons in Breast Cancer.- Osteosarcoma Management and Interferon.- Clinical Use of Interferons in the Treatment of Malignant Brain Tumors.- Interferon Treatment of Neuro-Endocrine Tumors of Pancreas and Gut.- The Role of Beta Interferon in the Treatment of Cervical Dysplasia.- Price: $ Delivery of Interferons to Target Cells by Monoclonal Antibodies: Potential for the Specific Targeting of Other Lymphokines H.

Hochkeppel, S. Alkan Pages   Get this from a library. The clinical potential of interferons: treatment of viral diseases and malignant tumors: proceedings of the International Conference on Clinical Potentials of Interferons in Viral Diseases and Malignant Tumors, held December[Reisaku Kōno; J Vilček;].

This book is an update of Interferon, published in by Dr. Jan Vilcek. The field of interferon research has since expanded from its former narrow treatment of interferon strictly as an antiviral substance, such that The Interferon System now encompasses cellular modulations ranging from immune alterations to cell proliferative restrictions to antitumor by: 7.

The Promise of Interferon Therapy for Parasitic Diseases.- II Clinical Uses in Cancer.- 8. Interferon Treatment of Non-Hodgkin's Lymphoma and Myeloma: A Model for Biotherapy.- 9.

The Role of Interferon Alpha in the Treatment of Hairy Cell Leukemia (HCL).- Clinical Studies of Alpha and Gamma Interferons in Chronic Myelogenous Leukemia.- The book is organized into four parts.

Part I presents papers on recombinant DNA production of interferon. It includes studies on the synthesis of human immune interferon in E. coli and monkey cells; the expression of human β interferon gene in heterologous cells; and the molecular activities of recombinant and hybrid leukocyte interferons.

Interferons: A Primer covers general information on interferon, including analysis, purification, production, properties, mechanism of action, and clinical uses.

Organized into 10 chapters, the book starts with a short history of interferon’s discovery by Isaacs and Lindenmann, followed by topics on assays for interferon, such as factors.

The potential of interferons as an antiviral panacea has not been realised. Interferon alfa is the only effective antiviral treatment for chronic infection with hepatitis B and chronic hepatitis C, but only a minority of patients is cured and interferon therapy is prohibitively expensive for developing countries.

Interferons (Alfa, Beta) Last Updated: J Recommendation. The COVID Treatment Guidelines Panel recommends against the use of interferons for the treatment of patients with severe and critical COVID, except in a clinical trial (AIII).There are insufficient data to recommend either for or against the use of interferon-beta for the.

What really revived interest in the possible clinical use of interferons, however, were limited trials, most of which employed interferon supplied by Cantell's laboratory, for the treatment of some human tumours, most notably renal cancers, malignant melanomas, lymphomas, and leukaemias.

Type 1 interferons have a broad antiviral activity in vitro and are currently evaluated in a clinical trial to treat MERS-CoV. In this review, we discuss preliminary data concerning the potential activity of type 1 interferons on SARS-CoV-2, and the relevance of evaluating these molecules in clinical trials for the treatment of COVID ISBN: OCLC Number: Description: 1 online resource ( pages) Contents: I Clinical Uses in Infectious and Immune Diseases Intranasal Interferons for Control of Respiratory Viral Infections Interferon Therapy of Herpes Simplex Dermal Infections and Papillomavirus Condylomata Interferon.

Interferons are a family of proteins shown to be effective in the treatment of viral (condylomata, acuminata) and neoplastic (hairy cell leukaemia and AIDS-related Kaposi’s sarcoma) diseases. To date, the clinical utility of the interferons has been hampered by an incomplete understanding of their mechanism of action.

However, there is supporting evidence. Type 1 interferons have a broad antiviral activity in vitro and are currently evaluated in a clinical trial to treat MERS-CoV.

In this review, we discuss preliminary data concerning the potential activity of type 1 interferons on SARS-CoV-2, and the relevance of evaluating these molecules in clinical trials for the treatment of COVID   The Story of Interferon, written by one of the principals in the clinical evolution of interferons, is a reassuring example that perseverance can bring an important scientific observation to clinical : Kari Cantell.

Interferon and its clinical potential. [D A J Tyrrell] Home. WorldCat Home About WorldCat Help. Search. Search for Library Items Search for Lists Search for Contacts Book: All Authors / Contributors: D A J Tyrrell.

Find more information about: ISBN: OCLC Number:   Interferons as a potential therapy for COVID New therapeutic interventions will likely require a long lead time for the development of approved drugs.

Thus, in light of the dire need and urgency to identify the treatment and control of COVID, a repurposing of IFNs and other approved drugs is a potential option in drug development for the control of coronavirus. The first report on the antitumor effects of interferon α/β (IFN-I) in mice was published 50 years ago.

IFN-α were the first immunotherapeutic drugs approved by the FDA for clinical use in cancer. However, their clinical use occurred at a time when most of their mechanisms of action were still unknown. Potential conflicts of interest. O., L.

P.-O., and R. are coinventors on patents for the interferon-λ4 protein that are held by the NCI. All other authors report no potential conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest.

Interferons (IFNs) were the first therapeutic protein effective in melanoma in humans. IFNs brought to clinical fruition years of research on the potential role of biological strategies for melanoma.

IFN-α2 is now licensed in more than 50 countries for more than a dozen clinical indications including melanoma. The book consists of 22 chapters that detail the history of virus discovery, selected viral diseases, and biotechnological advances.

The nature of the book is such that dissimilar topics are often covered within the span of a few pages, such as interferon biology and the history of smallpox in indigenous American populations.Psoriasis: Etiology, Immunopathogenesis and Therapies. Psoriasis is a chronic autoimmune skin disorder characterized by well-demarcated, raised areas of erythematous plaques, often covered by silvery scaling ().It is estimated that psoriasis affects million people worldwide (~% of the world population), including 2~4% of the US or European populations and ~% of the .Purchase Interferons - 1st Edition.

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